Novel optically active aminopentane derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 307/81 (2006.01) A61K 31/343 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2317036

Novel compounds involving optically pure (-)1-(benzofuran-2-yl)-2- propylaminopentane represented by formula (I), which is substantially free from the (+)-isomer and pharmacologically acceptable acid addition salts thereof. Because of being excellent in the effect of regulatively enhancing neurotransmitters catecholamines (i.e., CAE (Catecholaminergic Activity Enhancer) effect), these compounds are useful as psychotropic drugs and remedies for Parkinson's disease, depression and Alzheimer's disease.

Nouveaux composés contenant (-)-1-(benzofurane-2-yl)-2-propylaminopentane représentés par la formule (I) sensiblement exempte de l'isomère (+), ainsi que leur sels d'apport acide acceptables sur le plan pharmacologique: Etant donné qu'ils exercent un effet excellent sur l'augmentation de la régulation des catécholamines de neurotransmetteurs (i.e., CAE amplificateur de l'activité catécholaminergique), ces composés sont utiles en tant queédicaments psychotropes et remèdes contre les maladie de Parkinson, la dépression et la maladie d'Alzheimer.

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