C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/72 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/415 (2006.01) A61K 31/4166 (2006.01) A61K 31/45 (2006.01) A61K 31/55 (2006.01) A61K 31/65 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) C07C 33/03 (2006.01) C07C 233/05 (2006.01) C07C 235/34 (2006.01) C07D 209/34 (2006.01) C07D 209/36 (2006.01) C07D 209/38 (2006.01) C07D 223/10 (2006.01) C07D 233/02 (2006.01) C07D 233/74 (2006.01) C07D 233/76 (2006.01)
Patent
CA 2443906
The present invention is directed to novel themisone derivative compounds that have been modified to prevent the formation of the toxic metabolite, 2-phenyl- acrylamide. Compositions comprising such derivative compounds have activity as anesthetics and as neuroprotective agents.
La présente invention a trait à des composés dérivés de thémisone qui ont été modifiés en vue d'empêcher la formation du métabolite toxique, 2-phényle-acrylamide. L'invention concerne également des compositions contenant de tels composés dérivés présentant une activité en tant qu'anesthésiques et agents neuroprotecteurs. FIG. 2 : A PHASE I; DONNEES DE LA SOURIS B THEMISOME C INSTITUT NATIONAL DE MALADIES NEUROLOGIQUES ET DE CONGESTION CEREBRALE ; PROGRAMME DE DEVELOPPEMENT D'ANTICONVULSIVANTS D ELECTROCHOC MAXIMAL E DOSAGE (MG/KG) F ANIMAUX PROTEGES G DUREE D'ACTION (HEURES) H ICM-I-40N(17)
Sim & Mcburney
University Of Virginia Patent Foundation
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