C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2374729
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins ("OATPs"). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
La présente invention concerne des séquences d'acides nucléiques et d'acides aminés pour de nouvelles protéines de transfert d'anion organique ("OATP"). L'invention porte sur les OATP, ainsi que sur les vecteurs contenant les séquences d'ADNc, et sur les cellules hôtes contenant les vecteurs et les polypeptides comprenant tout ou partie d'une OATP. L'invention concerne également les utilisations des OATP comme médicaments de ciblage pour des organes spécifiques et comme modulateur de la concentration de substrats endogènes.
Hsiang Bonnie
Huang Xin
Kirchgessner Todd G.
Lynch Jean S.
Wang Zhaoqing
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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