C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/435 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2751777
The present invention is directed to the compounds of formula (I) wherein R, R1 and R2 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation- inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.
La présente invention porte sur les composés de la formule (I) dans laquelle R, R1 et R2 ont les significations données par les présentes, sur des procédés de fabrication desdits composés ainsi que sur des médicaments contenant lesdits composés. Les composés selon cette invention présentent une activité anti-proliférative et induisant une différenciation et sont donc utiles pour le traitement de maladies tel que le cancer chez les êtres humains ou les animaux.
Liang Chungen
Tang Guozhi
Wong Jason Christopher
Wu Xihan
Zhang Zhenshan
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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