C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) C07D 419/04 (2006.01)
Patent
CA 2606087
This invention relates to novel oxadiazole derivatives of formula (I) which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS) the preripheral nervous system (PNS) diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or dosorders related to inflammation, pain, and withdrawl symptoms caused by the termination of abuse of chemical substances.
L'invention concerne de nouveaux dérivés d'oxadiazole représentés par la formule (I), qui s'avèrent des modulateurs efficaces des récepteurs nicotiniques de l'acétylcholine. Du fait de leur profil pharmacologique, ces composés peuvent être utilisés dans le traitement de divers troubles tels que ceux liés au système cholinergique du système nerveux central (SNC), ainsi que dans le traitement des maladies du système nerveux périphérique (SNP), des maladies ou troubles liés à la contraction des muscles lisses, des maladies ou troubles endocriniens, des maladies ou troubles neurodégénératifs, des maladies ou troubles inflammatoires, de la douleur, ainsi que des symptômes de sevrage provoqués par l'arrêt ou l'abus de substances chimiques.
Dahl Bjarne H.
Joergensen Susanne
Olsen Gunnar M.
Peters Dan
Timmermann Daniel B.
Mccarthy Tetrault Llp
Neurosearch A/s
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