Novel oxazolone and pyrrolidinone-substituted arylamides

Details Novel oxazolone and pyrrolidinone-substituted arylamides Novel oxazolone and pyrrolidinone-substituted arylamides

C - Chemistry, Metallurgy

07

D

C07D 233/32 (2006.01) A61K 31/402 (2006.01) A61K 31/4166 (2006.01) A61K 31/421 (2006.01) A61K 31/423 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) C07D 207/27 (2006.01) C07D 263/20 (2006.01) C07D 401/14 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2754654

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

L'invention porte sur des composés représentés par la formule I : ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle formule X, Y, R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description. L'invention porte également sur des procédés d'utilisation des composés pour le traitement de maladies associées à P2X3 et/ou comme antagonistes des récepteurs P2X2/3 et sur des procédés de fabrication des composés.

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