Novel oxyntomodulin

Details Novel oxyntomodulin Novel oxyntomodulin

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01)

Patent

CA 2204645

A peptide represented by the following formula (I) or a pharmacologically acceptable salt thereof: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Asn-Asp-Tyr-Ser-Lys-Tyr- Leu-Glu-Thr-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Ser-Lys-Arg-Ser- Gly-Gly-Pro-Thr-OH. It has cardiotonic and insulin release accelerator effects and is useful for preventing or treating heart diseases or diabetes.

L'invention concerne un peptide représenté par la formule générale (I): H-His-Ser-Gln-Gly-Thr-Phe-Thr-Asn-Asp-Tyr-Ser-Lys-Tyr-Leu-Glu-Thr-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Ser-Lys-Arg-Ser-Gly-Gly-Pro-Thr-OH, ou un sel pharmacologiquement acceptable de ce peptide. Le peptide présenté a des effets tonicardiaques et accélérant la libération de l'insuline, et il peut être utilisé pour prévenir ou traiter des maladies cardiaques ou le diabète.

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