Novel p-terphenyl compounds

Details Novel p-terphenyl compounds Novel p-terphenyl compounds

C - Chemistry, Metallurgy

07

C

C07C 43/23 (2006.01) A61K 31/09 (2006.01) A61K 31/10 (2006.01) A61K 31/11 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) C07C 15/14 (2006.01) C07C 43/225 (2006.01) C07C 43/253 (2006.01) C07C 43/315 (2006.01) C07C 45/68 (2006.01) C07C 47/57 (2006.01) C07C 47/575 (2006.01) C07C 59/64 (2006.01) C07C 59/70 (2006.01) C07C 65/21 (2006.01) C07C 65/24 (2006.01) C07C 65/28 (2006.01)

Patent

CA 2261339

Selective IgE production inhibitors which contain substances inhibiting the production of IgE in the process of the differentiation of matured B cells into antibody-producing cells and the production of the antibody thereby while not or scarcely inhibiting the production of IgG, IgM and/or IgA to be produced simultaneously with IgE; compounds represented by general formula (I); a process for producing the same; and drugs containing the same. In said formula R1 to R13 represent each hydrogen, halogeno, lower alkyl, lower alkoxy, etc.; X represents O-, -CH2-, -NR14- or -S(O)p-; and Y represents lower alkyl or lower alkenyl.

Inhibiteurs sélectifs de la production d'IgE contenant des substances inhibant la production d'IgE dans le processus de différenciation de cellules B matures en cellules produisant des anticorps, et la production de l'anticorps, tout n'inhibant pas ou inhibant très peu la production d'IgG, IgM ou IgA produits simultanément avec IgE; composés représentés par la formule générale suivante (I), procédé de préparation de ces composés et médicaments contenant ces composés. Dans ladite formule, R?1¿ à R?13¿ représentent chacun hydrogène, halogéno, alkyle inférieur, alkoxy inférieur...; X représente O-, -CH¿2?-, -NR?14¿- ou -S(O)¿p?-; et Y représente alkyle inférieur ou alkényle inférieur.

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