Novel p2x7 epitopes

Details Novel p2x7 epitopes Novel p2x7 epitopes

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) G01N 33/53 (2006.01) G01N 33/536 (2006.01) G01N 33/563 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2737126

The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively binding to a non ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor, for the detection and treatment of disease conditions, especially cancer.

L'invention porte sur des récepteurs purinergiques (P2X), plus spécifiquement sur des récepteurs P2X7, sur la génération d'anticorps ainsi que sur l'utilisation d'anticorps et d'immunogènes aptes à se lier sélectivement à un récepteur P2X7 ne liant pas l'ATP mais non à un récepteur P2X7 liant l'ATP, utiles dans la détection et le traitement d'états pathologiques, notamment le cancer.

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