C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2481090
This invention relates to newly identified human pancortin polypeptides, the interaction of the pancortin polypeptides with a Pablo polypeptide, the use of such polypeptides, as well as the production of such polypeptides. The invention relates also to identifying compounds which modulate the activity of a pancortin polypeptides and/or the interaction of a pancortin-Pablo polypeptide interaction, wherein modulators can be agonists, antagonists and/or inhibitors of pancortin and/or the pancortin/Pablo interaction and therefore potentially useful in therapy.
La présente invention concerne des polypeptides de la pancortine humaine nouvellement identifiés, l'interaction des polypeptides de la pancortine précités avec un polypeptide Pablo, et l'utilisation et la production desdits polypeptides. L'invention se rapporte également à l'identification de composés qui modulent l'activité des polypeptides d'une pancortine et/ou l'interaction entre une pancortine et un polypeptide Pablo, les modulateurs pouvant être des agonistes, des antagonistes et/ou des inhibiteurs de la pancortine et/ou de l'interaction pancortine/Pablo et possédant par conséquent une utilité thérapeutique potentielle.
Gulukota Kamalakar
Mark Robert John
Wood Andrew Timothy
Torys Llp
Wyeth
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