C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2189741
The present invention relates to parasite astacin metalloendopeptidase and filariid cysteine protease proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases or cysteine proteases. The present invention also includes methods to obtain such nucleic acid molecules proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm.
L'invention concerne des protéines d'astacine-métalloendopeptidases de parasites et de cystéine-protéases de filaires, des molécules d'acide nucléique possédant des séquences codant lesdite protéines, des anticorps dirigés contre ledites protéines, ainsi que des composés pouvant inhiber les activités d'astacine-métalloendopeptidases de parasites ou de cystéine-protéases. L'invention comprend également des procédés d'obtention desdites molécules d'acide nucléique, desdites protéines, desdits anticorps et desdits inhibiteurs. Elle concerne également des compositions thérapeutiques comprenant lesdites molécules d'acide nucléique, lesdites protéines, lesdits anticorps et lesdits inhibiteurs, ainsi que leur utilisation afin de protéger des animaux contre la maladie provoquée par des parasites, tels que la filaire des chiens.
Frank Glenn R.
Grieve Robert B.
Tripp Cynthia Ann
Heska Corporation
Johnson Ernest Peter
LandOfFree
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