C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2153494
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U as well as to isolated nucleic acid sequences encoding P39, P22L or P20.5 or fragments thereof; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
La présente invention concerne des séquences d'acides nucléiques isolées chez des helminthes pouvant se lier, dans des conditions strictes, à au moins une portion de la séquence d'acides nucléiques p4 de D. immitis et/ou à au moins une portion de la séquence d'acides nucléiques p22U de D. immitis, ainsi qu'à des séquences d'acides nucléiques isolées codant les protéines P39, P22L ou P20.5, ou des fragments de celles-ci; les protéines isolées chez les helminthes qui sont codées par de telles séquences d'acides nucléiques et qui se lient de façon sélective à au moins un composant d'un immunsérum pouvant inhiber la croissance des helminthes; et les anticorps ciblant ces protéines isolées chez les helminthes. La présente invention concerne également des compositions thérapeutiques comprenant de telles séquences d'acides nucléiques, de telles protéines et/ou de tels anticorps. La présente invention concerne enfin des méthodes permettant de produire et d'utiliser de tels acides nucléiques, protéines, anticorps et compositions thérapeutiques, qui confèrent aux animaux une protection contre les helminthiases, et en particulier contre le ver du cour.
Frank Glenn R.
Grieve Robert B.
Mika-Grieve Marcia
Tripp Cynthia Ann
Colorado State University Research Foundation
Heska Corporation
Paravax Inc.
Ridout & Maybee Llp
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