C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2385428
The present invention is directed to polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
L'invention concerne de nouveaux polypeptides, acides nucléiques et molécules associées qui agissent sur le cycle cellulaire ou y sont associés. L'invention concerne également des vecteurs et cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules polypeptidiques chimères comprenant les polypeptides selon l'invention fusionnés à des séquences polypeptidiques hétérologues, des anticorps qui se fixent aux polypeptides selon l'invention et des procédés pour la production des polypeptides selon l'invention. L'invention concerne en outre des procédés pour l'identification de nouvelles compositions induisant la bioactivité du cycle cellulaire et l'utilisation de ces compositions dans le diagnostic et le traitement de maladies.
Huang Betty
Luo Ying
Rigel Pharmaceuticals Inc.
Smart & Biggar
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