Novel penam sulfones as beta-lactamase inhibitors

Details Novel penam sulfones as beta-lactamase inhibitors Novel penam sulfones as beta-lactamase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 499/87 (2006.01) A61K 31/43 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) C07D 499/00 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2228528

Novel 3-(substituted)-3-methyl-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylate, 4,4-dioxides of formula (I) wherein R2 is OR3 or NR4R5, which are of value for use in combination with .beta.-lactam antibiotics to increase the effectiveness of the antibiotics.

La présente invention se rapporte à de nouveaux 3-(substitué)-3-méthyl-4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylate, 4,4-dioxydes de Formule (I), dans laquelle R¿2? représente OR¿3? ou NR¿4?R¿5?, utiles lorsqu'ils sont combinés avec des bêta-lactamines en vue d'augmenter l'efficacité de ces antibiotiques.

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