Novel penicillin binding protein from streptococcus pneumoniae

Details Novel penicillin binding protein from streptococcus pneumoniae Novel penicillin binding protein from streptococcus pneumoniae

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/315 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265481

The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.

L'invention concerne des composés d'acides nucléiques isolés codant pour une nouvelle protéine fixatrice de pénicilline (PFP) de haut poids moléculaire, obtenue à partir de Streptococcus pneumoniae. Elle concerne également des vecteurs et des cellules hôtes hétérologues transformées permettant d'exprimer la PFP, ainsi qu'une méthode permettant d'identifier des composés qui se lient à la PFP et/ou inhibent son activité enzymatique.

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