Novel peptide amphiphiles having improved solubility and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 17/02 (2006.01) C12N 5/079 (2010.01) A61K 9/107 (2006.01) A61K 38/08 (2006.01) A61P 25/00 (2006.01) C07K 1/04 (2006.01) C07K 1/107 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2690772

Disclosed herein are novel peptide amphiphile molecules and compositions discovered to possess improved solubility in aqueous buffers which, in tum, facilitates purification required for pharmaceutical applications, particularly for in vivo administration to human patients. In addition, gels of such peptide amphiphile compositions are shown herein to possess unexpectedly superior gelation kinetics and rheological properties, including an increased mechanical stiffness, which better mimics the mechanical properties of natural central nervous system tissues.

L'invention concerne de nouvelles molécules et compositions de peptides amphiphiles découvertes comme possédant une solubilité améliorée dans les tampons aqueux qui facilitent eux-mêmes la purification nécessaire pour les utilisations pharmaceutiques, en particulier pour l'administration in vivo aux patients humains. De plus, des gels de ces compositions de peptides amphiphiles se sont avérés posséder des propriétés cinétiques et rhéologiques de gélification supérieures inattendues, comprenant une rigidité mécanique accrue qui imite mieux les propriétés mécaniques des tissus du système nerveux central naturel.

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