Novel peptide and pharmaceutical use of the same

Details Novel peptide and pharmaceutical use of the same Novel peptide and pharmaceutical use of the same

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 9/70 (2006.01) A61K 38/30 (2006.01) A61P 17/02 (2006.01) A61P 27/02 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01) C07K 14/65 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2469134

It is intended to search for the minimum activity expression units of insulin- like growth factor-I and find out medicinal uses thereof in the fields of ophthalmology and dermatology. Combined use of a peptide containing the amino acid sequence Ser-Ser-Ser-Arg and a peptide containing the amino acid sequence Phe-Gly-Leu-Met-NH2, which are the minimum activity expression units of insulin-like growth factor-I, is efficacious in treating keratic injury and remarkably promotes wound healing in the skin.

L'objectif de l'invention est de rechercher les unités présentant une expression d'activité minimale du facteur de croissance I analogue à l'insuline et de trouver des utilisations de ces unités en tant que médicaments en ophtalmologie et en dermatologie. L'utilisation combinée d'un peptide contenant la séquence d'aminoacides Ser-Ser-Ser-Arg et d'un peptide contenant la séquence d'aminoacides Phe-Gly-Leu-Met-NH<sb>2</sb>, qui sont les unités présentant une expression d'activité minimale du facteur de croissance I analogue à l'insuline, se montre efficace dans le traitement de lésions kératiques et stimule de façon remarquable la cicatrisation de blessures de la peau.

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