C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/36 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2168964
The present invention provides compounds or salts thereof, that are represented by the general formula (I): Pro-Ser-A-B-Asp-C-D, wherein A is an amino acid other than amino acids having a guanidino group at a side chain, B is an amino acid, C is an amino acid having a hydrophobic group at a side chain and D is a hydroxy or an amino group. The compounds and salts thereof of the present invention are useful since they have excellent platelet aggregation-inhibiting and blood coagulation-inhibiting activities and are highly safe.
L'invention concerne des composés ou leurs sels représentés par la formule générale (I): Pro-Ser-A-B-Asp-C-D, dans laquelle A représente un acide aminé autre que des acides aminés présentant un groupe guanidino au niveau d'une chaîne latérale, B représente un acide aminé, C représente un acide aminé présentant un groupe hydrophobe au niveau d'une chaîne latérale, et D représente un groupe aminé ou hydroxy. Les composés de l'invention et leur sels sont utiles car ils présentent d'excellentes activités inhibitrices de l'agrégation plaquettaire et de la coagulation sanguine, ils sont sans danger.
Hayashi Yoshio
Katada Jun
Sato Yoshimi
Nippon Steel Corporation
Smart & Biggar
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