Novel peptide compound

Details Novel peptide compound Novel peptide compound

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 16/44 (2006.01) C12P 21/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2631292

Disclosed is a novel compound represented by the formula (1) below or a pharmaceutically acceptable salt thereof. Also disclosed is a use of such a compound or salt in cancer immunotherapy. (1) [In the formula, X represents a tyrosine residue or a methionine residue; Y and Z respectively represent a single bond or the like; R1 represents a hydrogen atom or the like; R2 represents a hydroxyl group or the like; R3 represents a hydrogen atom, an alkyl group, an amino group or the like; R4 represents a hydrogen atom, an alkyl group, a carboxy group or the like; m represents 1 or 2; and n represents an integer of 0-2. In this connection, when n is 0, R3 represents a hydrogen atom or an alkyl group.]

L~invention concerne un nouveau composé représenté par la formule (1) ci-dessous ou un de ses sels pharmaceutiquement acceptables. L~invention concerne également l~utilisation d~un tel composé ou sel dans l~immunothérapie de cancers. (1) [Dans la formule, X représente un résidu de tyrosine ou un résidu de méthionine ; Y et Z représentent respectivement une liaison simple ou analogue ; R1 représente un atome d~hydrogène ou analogue ; R2 représente un groupement hydroxyle ou analogue ; R3 représente un atome d~hydrogène, un groupement alkyle, un groupement amino ou analogue ; R4 représente un atome d~hydrogène, un groupement alkyle, un groupement carboxy ou analogue ; m représente 1 ou 2 ; et n représente un entier compris entre 0 et 2. A ce propos lorsque n vaut 0, R3 représente un atome d~hydrogène ou un groupement alkyle.]

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