Novel peptide having elastase inhibitor activity and process...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/15 (2006.01) C07K 14/81 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2134240

A novel peptide having an elastase inhibitor activity and being useful as a remedy or preventive for diseases caused by elastase is produced by partially modifying the constitutive amino acid of HI-8 present on the C-terminal side of a human urine trypsin inhibitor and having a trypsin inhibitor activity. The invention also provides a gene coding for the peptide, a plasmid containing the gene, a recombinant microbe holding the plasmid, and a process for producing the peptide by using the recombinant microbe.

On produit un nouveau peptide présentant une activité inhibitrice de l'élastase utilisé pour le traitement ou la prophylaxie de maladies provoquées par l'élastase en modifiant partiellement l'acide aminé, constitutif de HI-8 présent sur le côté de l'extrémité C d'un inhibiteur de la trypsine urinaire humaine et présentant une activité inhibitrice de la trypsine. L'invention concerne également un gène codant pour le peptide, un plasmide contenant ledit gène, un microbe recombiné contenant ledit plasmide et un procédé de production dudit peptide au moyen dudit microbe recombiné.

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