Novel peptide inhibitors of calmodulin

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223501

The present invention relates to novel family of peptides which inhibit calmodulin and which have the general structure Ac-A1-B2-C3-D4-E5-F6-NH2, (SEQ ID No. 1), wherein A1 is (D)Leu or Leu, B2 is (D)Gln, Gln, (D)Trp, or Trp, C3 is (D)Arg, Arg, (D)Ile, or Ile, D4 is (D)Ile, Ile, (D)His, or His, E5 is (D)Leu, Leu, (D)His, or His, and F6 is (D)Trp, Trp, (D)Arg, or Arg. The novel peptides can be used to inhibit the activity of calmodulin. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a calmodulin-inhibitor peptide. These compositions can be used to treat calmodulin related disorders.

L'invention concerne une nouvelle famille de peptides qui inhibent la calmoduline et qui présentent la structure générale Ac-A1-B2-C3-D4-E5-F6-NH¿2?, (ID SEQ No1), dans laquelle A1 représente (D)Leu ou Leu, B2 représente (D)Gln, Gln, (D)Trp ou Trp, C3 représente (D)Arg, Arg, (D)Ile ou Ile, D4 représente (D)Ile, Ile, (D)His ou His, E5 représente (D)Leu, Leu, (D)His ou His, et F6 représente (D)Trp, Trp, (D)Arg ou Arg. Ces nouveaux peptides peuvent être utilisés pour inhiber l'activité de la calmoduline. De plus, l'invention porte sur des compositions pharmaceutiques comprenant un véhicule pharmaceutiquement acceptable et un peptide inhibant la calmoduline. Ces compositions peuvent être utilisées pour traiter des troubles liés à la calmoduline.

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