C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 29/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441210
The present invention relates to novel peptides which are useful as antagonists of the .beta.2 integrins, to pharmaceutical compositions comprising these peptides, to the use of the novel peptides for the manufacture of pharmaceutical compositions for the treatment of inflammatory diseases and human leukemias and for inhibiting leukocyte cell adhesion and migration in general, to a method for therapeutic or prophylactic treatment of inflammatory diseases and human leukemias and to the use of the novel peptides as .beta.2 integrin antagonists for biochemical isolation and purification procedures in vitro.
L'invention concerne de nouveaux peptides qui servent d'antagonistes des intégrines .beta.¿2? ; des compositions pharmaceutiques comprenant ces peptides ; l'utilisation de ces nouveaux peptides pour la production de compositions pharmaceutiques servant au traitement de maladies inflammatoires et de leucémies humaines et servant à inhiber l'adhésion cellulaire des leucocytes et la migration cellulaire en général ; une méthode de traitement thérapeutique et prophylactique de maladies inflammatoires et de leucémies humaines, et l'utilisation de ces nouveaux peptides comme antagonistes des intégrines .beta.¿2? pour des procédures d'isolation et de purification biochimiques <i>in vitro</i>.
Gahmberg Carl G.
Koivunen Erkki
Ctt Cancer Targeting Technologies Oy
Mccarthy Tetrault Llp
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