C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2276108
The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging--suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.
L'invention concerne: un polypeptide susceptible de retarder le vieillissement; un ADN codant ce polypeptide; un procédé d'élevage de bétail faisant appel à cet ADN; un ADN recombiné obtenu par intégration de cet ADN dans un vecteur; un transformant contenant ce produit de recombinaison; un procédé permettant de produire le polypeptide susmentionné au moyen du transformant; un anticorps susceptible de reconnaître ledit polypeptide; un ligand destiné à ce polypeptide; un composé inhibant la liaison spécifique entre le polypeptide et ce ligand; un composé stimulant l'expression du gène retardant le vieillissement codant le polypeptide retardant le vieillissement; un oligonucléotide présentant une séquence constituée de 10 à 50 bases de la séquence des bases de l'ADN susmentionnée; et des remèdes permettant de lutter contre le vieillissement prématuré, contre des maladies de l'adulte, ainsi que des agents de résistance au vieillissement préparés à l'aide dudit polypeptide.
Iida Akihiro
Kuroo Makoto
Nabeshima Youichi
Sekine Susumu
Goudreau Gage Dubuc
Kyowa Hakko Kogyo Co. Ltd.
Shirankai Kyoto University Faculty Of Medicine Alumni Associatio
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