Novel peptides, and antidementia agents containing the same

Details Novel peptides, and antidementia agents containing the same Novel peptides, and antidementia agents containing the same

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/113 (2006.01) C07K 5/117 (2006.01) C07K 7/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2014590

Disclosed is a novel peptide having one of the formulae: Image (A and B are the amino acids: wherein if A is D- or L-Pro, B is Har or Cit; if A is D-Pro, B is D-Arg, and if B is D- or L-Arg, A is Sar, Pip, Aze or Arg) Asn-A-L-(D-)Pro-Arg-(Gly)n (A is Ser, Thr or Ala, n is 1 or 0) A-Ser-Pip-Arg (A is Pro-Asn-, Asn- or Pro-) Image (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or .beta.-Ala, W is a hydrogen atom or a group having the formula: Image or a peptide having the formula: Image wherein A and B hare the same meanings as mentioned above, respectively pGlu-Asn-Ser-A-B-(Gly)n (A is Aze, D- or L-Pro, Pip or Sar, B is D- or L-Arg, Cit, Har, Lys or Orn, n is 1 or 0) and Pro-(Asn)m-Ser-L-(D-)Pro-Arg-(Gly)n (m and n are independently 0 or 1) their functional derivatives, and pharmaceutically acceptable salts thereof.

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