Novel peptides and compositions which modulate apoptosis

Details Novel peptides and compositions which modulate apoptosis Novel peptides and compositions which modulate apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220753

The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain", which is essential both to Bak's interaction with Bcl-x L, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.

Cette invention a trait à de nouveaux peptides et à de nouvelles compositions capable de moduler l'apoptose cellulaire, ainsi qu'à des procédés de modulation d'apoptose faisant appel aux peptides et aux compositions selon l'invention. Un aspect de celle-ci porte sur un nouveau peptide dénommé "domaine GD" et dont le rôle est essentiel tant pour ce qui relève d'une interaction de Bak avec Bcl-x¿L? que pour ce qui relève de la fonction cytotoxique de Bak. Il est également fait état de procédé permettant d'identifier des agonistes ou des antagonistes de la fonction du domaine GD, celui-ci étant à l'origine d'une régulation d'interactions protéine clé/protéine, régulations importantes au niveau de l'activité de nombreuses molécules de régulation de la mort cellulaire.

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