Novel peptides of the respiratory syncytial virus (rsv) g...

Details Novel peptides of the respiratory syncytial virus (rsv) g... Novel peptides of the respiratory syncytial virus (rsv) g...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01) C07K 16/08 (2006.01)

Patent

CA 2455360

The invention concerns novel immunogenic peptides derived from the RSV G protein of the sub-group A or B comprising at least: a first peptide derived from the BRSV G protein of sub-group A or B including at least in position 173, 176, 182 and 186 a cysteine, and whereof the C-terminal end includes at most the amino acid in position 192; and a second peptide derived from the RSV protein of sub-group A or B, said second peptide being located downstream of said first protein, so that the immunogenic peptide produced has a disulphide bond linking residues 173 and 186 and a second disulphide bond linking residues 176 and 182.

La présente invention se rapporte à de nouveaux peptides immunogènes dérivés de la protéine G du VRS du sous-groupe A ou B comprenant au moins: un premier peptide dérivé de la protéine G du VRS du sous-groupe A ou B comprenant au moins en position 173, 176, 182 et 186 une cystéine, et dont l'extrémité C- terminale comprend au plus l'acide aminé en position 192; et un deuxième peptide dérivé d'une protéine du VRS du sous-groupe A ou B, ledit deuxième peptide étant situé en aval dudit premier peptide, de manière à ce que le peptide immunogène produit présente un pont disulfure reliant les résidus 173 et 186 et un deuxième pont disulfure reliant les résidus 176 et 182.

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