C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2596674
The invention relates to the research and identification of novel peptides which interact with anti-apoptotic members of the family of Bcl-2 proteins by means of the double-hybrid system. More specifically, the invention relates to a method of screening and identifying modulators of the protein interaction between said novel peptides and the anti-apoptotic members of the family of Bcl-2 proteins. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death.
L'invention s'inscrit dans le cadre de la recherche et l'identification de nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de protéines Bcl-2 par le système du double hybride. L'invention a pour objet une méthode de criblage et d'identification de modulateurs de l'interaction protéique entre ces nouveaux peptides et les membres anti- apoptotiques de la famille de protéines Bcl-2. Les modulateurs identifiés sur la base de cette méthode sont administrés, aux patients atteints de cancers afin d'induire de la mort cellulaire programmée de type apoptotique et/ou autophagique chez ces derniers.
Geneste Olivier
Hickman John
Rain Jean-Christophe
Hybrigenics
Les Laboratoires Servier
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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