Novel pgc-1 isoforms and uses therefor

Details Novel pgc-1 isoforms and uses therefor Novel pgc-1 isoforms and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) C12N 1/20 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2451395

The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules isolées d'acide nucléique, appelées molécules d'acide nucléique PGC-1b et PGC-1c, qui codent pour de nouveaux isoformes de membres de la famille des gènes PGC-1. Elle a également trait à des molécules d'acide nucléique antisens, à des vecteurs d'expression recombinés contenant des molécules d'acide nucléique de PGC-1, à des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression, et à des animaux transgéniques non humains dans lesquels un gène PGC-1 a été introduit ou disrupté. L'invention se réfère de plus à des protéines isolées de PGC-1, à des protéines de fusion, à des peptides antigéniques et à des anticorps anti-PGC-1 ; et à des procédés diagnostiques utilisant les compositions de l'invention.

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