Novel pharmaceutical composition comprising a disintegration...

A - Human Necessities – 61 – K

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Details

A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 31/4184 (2006.01) A61K 47/02 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2644179

The present invention relates to a stable pharmaceutical composition comprising a pharmaceutically active substance having poor water solubility dispersed in a pharmaceutically acceptable disintegration matrix, said disintegration matrix comprising at least one pharmaceutically acceptable disintegrant, a pharmaceutically acceptable basic agent provided in a molar ratio of basic agent to active substance of 1:1 to 10:1, a water-insoluble pharmaceutically acceptable diluent, optionally, if desired or necessary at least one pharmaceutically acceptable excipients and/or pharmaceutically acceptable adjuvants, and optionally a pharmaceutically acceptable surfactant or emulsifier. The present invention also provides a process to make such.

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