Novel pharmaceutical composition for the preparation of a...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/46 (2006.01) A61K 31/60 (2006.01)

Patent

CA 2175470

The present invention relates to a novel pharmaceutical composition for the preparation of a stable powder containing an association of acetylsalicylic acid and metoclopramid as the active ingredient. According to the invention, this composition comprises, as the active ingredient, an effective amount of a water-soluble salt or complex of acetylsalicylic acid in association with metoclopramid or one of its pharmaceutically acceptable salts, and at least one pharmaceutically acceptable hydrophilic polymer in a sufficient amount to stabilize the metoclopramid. This composition has a remarkable stability in powder form and can be used to prepare sachets for the treatment of migraine.

Le présente invention a pour objet une nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. Selon l'invention, cette composition comprend, à titre d'ingrédient actif, une quantité efficace d'un sel ou complexe soluble dans l'eau de l'acide acétylsalicylique en association avec du métoclopramide ou l'un de ses sels pharmaceutiquement acceptables; et au moins un polymère hydrophile pharmaceutiquement acceptable en une quantité suffisante pour stabiliser le métoclopramide. Cette composition présente une stabilité remarquable sous forme de poudre, et peut être utilisée pour la préparation de sachets destinés au traitement de la migraine.

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