Novel pharmaceutical dosage forms and method for producing same

Details Novel pharmaceutical dosage forms and method for producing same Novel pharmaceutical dosage forms and method for producing same

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2471948

Pharmaceutical dosage forms are produced by injection molding a mixture of an active agent and a polymer under pressure, in the presence of a gas or supercritical fluid. Rapid release of the pressure causes the mixture to form a microcellular or supermicrocellular solid. The release of pressure takes place in the mold. The process is especially useful for producing durable flash-dissolve and gastro-retentive tablets.

Des formes posologiques pharmaceutiques sont produites au moyen d'un moulage par injection d'un mélange constitué d'un agent actif et d'un polymère sous pression, en présence d'un gaz ou d'un fluide supercritique. La détente rapide de la pression provoque la formation par le mélange d'un solide microcellulaire ou supermicrocellulaire. La détente de pression se produit dans le moule. Ce procédé s'avère particulièrement utile pour la production de comprimés solides dotés d'une capacité de dissolution éclair et de gastro-rétention.

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