Novel pharmaceutically active flavilium compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 311/60 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2122897

The present invention relates to novel flavilium derivatives of general formula (I) wherein X is an anion, whereby a pharmaceutically acceptable salt is formed, R1 and R2 are independently selected from hydrogen or -OY, in which Y is hydrogen, .alpha.-amino-acyl or amino-alkyl having 1 to 5 carbon atoms; R5 is hydrogen, .alpha.-amino-acyl or amino-alkyl having 1 to 5 carbon atoms; R3, R4, and R7 independently are hydrogen or alkyl having 1 to 5 carbon atoms, R6 is hydrogen, hydroxy or alkyl having 1 to 5 carbon atoms. The compounds of general formula (I) possess an outstanding selective anti-viral effect.

La présente invention concerne de nouveaux dérivés de flavilium selon la formule générale (I). Dans cette formule, X est un anion nontoxique, R1 et R2 sont choisis d'une manière indépendante parmi l'hydrogène ou un groupe -OY, dans lequel Y est hydrogène, un groupe alpha-aminoacyle ou un groupe aminoalkyle ayant de 1 à 5 atomes de carbone; R5 est hydrogène, un groupe alpha-aminoacyle ou un groupe aminoalkyle ayant de 1 à 5 atomes de carbone; R3, R4 et R7 sont d'une manière indépendante hydrogène ou un groupe alkyle ayant de 1 à 5 atomes de carbone; R6 est hydrogène, un groupe hydroxy ou un groupe alkyle ayant de 1 à 5 atomes de carbone. Les composés de la formule générale (I) ont une activité sélective antivirale remarquable.

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