Novel phenyl-imidazopyridines and pyridazines

Details Novel phenyl-imidazopyridines and pyridazines Novel phenyl-imidazopyridines and pyridazines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/502 (2006.01) A61K 31/5025 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/5415 (2006.01) A61K 31/549 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2726460

6-Phenyl-imidazo[1,2-a]pyridine and 6-Phenylimidazo[1,2-b]pyridazine derivatives according to generic Formulae I-V: wherein, variables Q, R, X, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

Linvention concerne des dérivés de 6-phényl-imidazo[1,2-a]pyridine et de 6-phényl-imidazo[1,2-b]pyridazine selon les formules génériques I à V : dans lesquelles les variables Q, R, X, Y1, Y2, Y3, Y4, n et m sont telles que définies dans la description, qui inhibent Btk. Les composés décrits ici sont utiles pour moduler l'activité de Btk et traiter des maladies associées à une activité excessive de Btk. Les composés sont en outre utiles pour traiter des maladies inflammatoires et auto-immunes associées à une prolifération aberrante des cellules B, telles que la polyarthrite rhumatoïde. L'invention porte également sur des compositions renfermant les composés des formules I à V et au moins un support, diluant ou excipient.

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