C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/02 (2006.01) C07C 233/66 (2006.01) C07C 233/80 (2006.01) C07D 213/82 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2591321
The present invention relates to novel intermediates useful for the preparation of novel phenylaminopyrimidine derivatives, novel phenylaminopyrimidine derivatives. Pharmaceutical composition containing the novel phenylaminopyrimidine derivatives and processes for their preparation. The invention particularly relates to novel Phenyl pyrimidine amine derivatives of the general formula (I). The novel compounds of the formula 1 can be used in the therapy of Chronic Myeloid Leukemia (CML). Since the IC50; 191 values of these molecules are in the range 0.1 to 10.0 nm, these novel compounds are potentially useful for the treatment of CML.
L'invention concerne de nouveaux intermédiaires utiles pour la préparation de nouveaux dérivés de phénylaminopyrimidine, ainsi que ces dérivés eux-mêmes. Elle concerne également une composition pharmaceutique contenant ces nouveaux dérivés de phénylaminopyrimidine et des méthodes servant à les préparer. Elle concerne, en particulier, de nouveaux dérivés de phénylaminopyrimidine représentés par la formule (I). On peut utiliser ces nouveaux composés afin de traiter la leucémie myéloïde chronique (CML). Etant donné que les valeurs IC50 de ces molécules sont de l'ordre de 0,1 à10 nm, ces nouveaux composés sont potentiellement utiles pour traiter CML.
Adibhatla Kali Satya Bhujanga Rao
Chowdary Nannapaneni Venkaiah
Kompella Amala Kishan
Podili Khadgapathi
Rachakonda Sreenivas
Adibhatla Kali Satya Bhujanga Rao
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chowdary Nannapaneni Venkaiah
Kompella Amala Kishan
Natco Pharma Limited
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