Novel phenylethyl and phenylpropylamines

Details Novel phenylethyl and phenylpropylamines Novel phenylethyl and phenylpropylamines

C - Chemistry, Metallurgy

07

C

C07C 233/62 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) C07C 237/06 (2006.01) C07C 255/58 (2006.01) C07C 255/60 (2006.01) C07C 309/65 (2006.01) C07D 207/404 (2006.01) C07D 207/408 (2006.01) C07D 209/48 (2006.01) C07D 221/20 (2006.01) C07D 223/10 (2006.01)

Patent

CA 2150005

Compounds of general formula (I) wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group, R2, R3 and R13 are selected from the following groups: H, OH, OR14, halogen, CO2R9, CN, CF3, NO2, NH2, COCH3, OSO2CF3, OSO2CH3, CONR10R11 and OCOR12, R is (1), (2), (3) or (4) wherein R4, R5, R6, R7, R8, W, n3 and n4 have the definitions of the claims, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment of psychiatric disorders.

Sont décrits des composés de formule générale (I) où Z est une chaîne saturée ou insaturée de 3 à 6 atomes de carbone, m vaut 2 ou 3, R¿1? est un atome d'hydrogène, ou bien un groupe alkyle C¿1-4? à chaîne droite ou ramifiée, R¿2?, R¿3? et R¿13? sont choisis dans les groupes suivants: H, OH, OR¿14?, halogène, CO¿2?R¿9?, CN, CF¿3?, NO¿2?, NH¿2?, COCH¿3?, OSO¿2?CF¿3?, OSO¿2?CH¿3?, CONR¿10?R¿11? et OCOR¿12?, R est 1), 2), 3) ou bien 4) où R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, W, n¿3? et n¿4? ont les notations définies dans les revendications. Sont également décrits des procédés pour leur préparation, des préparations pharmaceutiques les contenant et l'utilisation de ces composés dans le traitement de troubles psychiatriques.

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