C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/4353 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2728335
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective, amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).
La présente invention concerne une composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un composé de l'invention et un vecteur pharmaceutiquement admis. L'invention concerne également des procédés d'élaboration des composés représentés par la formule (I). L'invention concerne aussi un procédé qui permet de traiter un patient atteint de troubles neurodégénératifs et qui consiste en l'administration à ce patient d'une quantité thérapeutiquement efficace d'un composé représenté par la formule (I). L'invention concerne en outre un procédé qui permet de traiter un patient pharmacodépendant et qui consiste en l'administration à ce patient d'une quantité thérapeutiquement efficace d'un composé représenté par la formule (I). L'invention concerne enfin un procédé qui permet de traiter un patient souffrant de troubles mentaux et qui consiste en l'administration à ce patient d'une quantité thérapeutiquement efficace d'un composé représenté par la formule (I).
Farah Mohamed M.
Kehler Jan
Kilburn John Paul
Langgard Morten
Nielsen Jacob
Goudreau Gage Dubuc
H. Lundbeck A/s
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