Novel phenylimidazopyrazines

Details Novel phenylimidazopyrazines Novel phenylimidazopyrazines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2725512

6-Phenyl-imidazo[1,2-a]pyrazine derivatives according to generic Formulae I-V: wherein variables Q, R, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

Linvention concerne des dérivés de 6-phényl-imidazo[1,2-a]pyrazine selon les formules génériques I à V : dans lesquelles les variables Q, R, Y1, Y2, Y3, Y4, n et m sont telles que définies dans la description, et qui inhibent Btk. Les composés décrits ici sont utiles pour moduler l'activité de Btk et traiter des maladies associées à une activité excessive de Btk. Les composés sont également utiles pour traiter des maladies inflammatoires et auto-immunes associées à une prolifération aberrante des cellules B, telles que la polyarthrite rhumatoïde. L'invention porte également sur des compositions renfermant des composés des formules I à V et au moins un support, diluant ou excipient.

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