C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/30 (2006.01) A61K 31/662 (2006.01) A61P 5/14 (2006.01) C07F 9/32 (2006.01) C07F 9/36 (2006.01) C07F 9/40 (2006.01) C07F 9/48 (2006.01) C07F 9/572 (2006.01) C07F 9/655 (2006.01) C07F 9/6571 (2006.01)
Patent
CA 2606498
The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
L'invention concerne des composés de mimétiques T3 contenant de l'acide phosphonique et des monoesters de ceux-ci, des stéréo-isomères, des sels pharmaceutiquement acceptables, des cocristaux et des promédicaments de ces composés, ainsi que des sels pharmaceutiquement acceptables et des cocristaux de ces promédicaments. L'invention concerne également leur préparation et leurs utilisations pour prévenir et/ou traiter des maladies métaboliques telles que l'obésité, la stéato-hépatite non alcoolique, l'hypercholestérolémie et l'hyperlipidémie, ainsi que des troubles associés comme l'athérosclérose, la maladie coronarienne, l'intolérance au glucose, le syndrome métabolique ou syndrome X et le diabète.
Boyer Serge H.
Erion Mark D.
Jiang Hongjian
Metabasis Therapeutics Inc.
Smart & Biggar
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