Novel phosphodiesterase inhibitors

Details Novel phosphodiesterase inhibitors Novel phosphodiesterase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/10 (2006.01) A61K 31/36 (2006.01) A61P 29/00 (2006.01) C07D 493/10 (2006.01) C07D 495/10 (2006.01)

Patent

CA 2676933

The present invention relates to a compound according to formula I, wherein X, A, G, E, R1, R2, R3 are as shown herein; and pharmaceutically acceptable salts, hydrates, N- oxides or solvates hereof, said compounds are used as phoshodiesterase inhibitors in particular PDE4 inhibitors. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

La présente invention porte sur un composé représenté par la formule (I), dans laquelle X, A, G, E, R1, R2, R3 sont tels que définis ici; et sur des sels, hydrates, N-oxydes ou solvates pharmaceutiquement acceptables de ce composé. L'invention porte également sur lesdits composés pour une utilisation en thérapie, sur des compositions pharmaceutiques comprenant lesdits composés, sur des procédés de traitement des maladies, par exemple des maladies dermiques, par ledit composé, et sur l'utilisation desdits composés dans la fabrication de médicaments.

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