Novel phosphoramidate and phophorothioamidate oligomeric...

Details Novel phosphoramidate and phophorothioamidate oligomeric... Novel phosphoramidate and phophorothioamidate oligomeric...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07F 9/09 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2184005

Compounds are provided having structure (1), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step or during a coupling step.

Les composés selon l'invention ont une structure correspondant à la formule indiquée, où les groupes L sont des segments squelette, les groupes Y et Y des groupes fonctionnels pour interagir avec les molécules cibles à étudier, où les groupes X représentent oxygène ou soufre, et les groupes E représentent H; on prépare les groupes conjugués ou les groupes intermédiares utilisés pendant la synthèse de ces composés au moyen de produits chimiques du type H phosphoné, les groupes fonctionnels étant ajoutés pendant une étape d'oxydation ou de couplage.

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