C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 11/04 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2525328
Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.
L'invention concerne de nouveaux composés de phosphotétrahydropyrane mimant une mannose-6-phosphate, ces composés étant plus résistants aux phosphatases et aux mannosidases, et des compositions pharmaceutiques renfermant ledit composé. Ces composés et ces compositions inhibent la migration des lymphocytes T du sang vers des tissus ou d'autres sites extravasculaires. Lorsque cette migration est inhibée, on utilise lesdits composés pour traiter des maladies ou des troubles induits au moins en partie par la migration des lymphocytes T. Lesdits troubles et maladies comprennent l'arthrite rhumatoïde, la sclérose en plaques, l'encéphalomyélite aiguë disséminée, le psoriasis, les maladies intestinales inflammatoires, la dermite induite par les lymphocytes T, la kératite stromale, l'uvéite, la thyroïdite, la sialite et le diabète de type I.
Bartell Gavin
Cowden William
Eschler Bart
March Darren
Robertson Alan
Pharmaxis Pty Ltd.
Sim & Mcburney
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