C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.1, 530/7.3
C07K 14/585 (2006.01) A61K 38/23 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2030795
A novel physiologically active peptide having the following amino acid sequence: (see above formula) wherein X1 stands for Ser-Thr or Thr-Ser; X2 stands for Met, Gly, Ala, Val, n-Val, Pro, Leu or n-Leu; X3 stands for Glu; X4 stands for Leu-Gln-Thr, Gln-Thr, Leu or Gly-Gln-Thr; X5 stands for Val-Gly-Ala or Ser-Gly-Thr; R stands for H, NH2, N-acyl or N-alkyl; X6 stands for CO-NH or NH-CO; X7 stands for an amino acid sequence at the 2- to 6-positions of native calcitonin, and having 0 to 6 amino acids, X8 stands for an amino acid sequence at the 8- to 32-positions of native calcitonin; and each of n1 and n2 is an integer of 0 to 19 and n1 + n2 is 1 to 20, or a pharmacologically acceptable salt thereof, and a calcium metabolism-regulating agent comprising, as an effective ingredient, the above-mentioned peptide or salt, and a customary pharmaceutical carrier.
Hanamura Satoshi
Marumoto Masahiko
Orlowski Ronald C.
Sakamoto Kenji
Waki Yoshihiro
G. Ronald Bell & Associates
Tsumura & Co.
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