C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/365 (2006.01) A61K 31/496 (2006.01) C07D 407/06 (2006.01)
Patent
CA 2486728
The present invention relates to a compound represented by the formula (I): (see formula I) (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
L'invention porte sur des composés représentés par la formule générale suivante (I) ; sur des sels pharmaceutiquement acceptables de ces derniers ou des hydrates de ces composés : R?3¿, R?6¿, R?7¿ et R?21¿ étant identiques ou différents et chacun représentant hydroxy, etc. En raison de leur faculté d'inhiber l'angiogenèse (notamment, la production de VEGF), ces composés (I) sont utiles en tant que remèdes contre les cancers solides.
Fukuda Yoshio
Kanada Regina Mikie
Kotake Yoshihiko
Nagai Mitsuo
Nakashima Takashi
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Mercian Corporation
Smart & Biggar
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