C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/4985 (2006.01) A61K 31/501 (2006.01) A61K 31/5025 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 31/5365 (2006.01) A61K 31/5377 (2006.01) A61K 31/549 (2006.01) A61P 31/14 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D
Patent
CA 2649521
The present invention relates to a compound represented by the following formula [I-D1] (see formula I-D1] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof and an anti-HCV agent and an HCV polymerase inhibitor containing this compound. The invention further relates to uses of said compound as anti-HCV agent based on the HCV polymerase inhibitory activity, and for the prophylaxis or treatment of hepatitis C.
La présente invention concerne un composé représenté par la formule générale [I] présentée ci-dessous, son sel acceptable d'un point de vue pharmaceutique ou un solvate du composé ou du sel. L'invention porte aussi sur un agent anti-VHC et un inhibiteur de la polymérase du VHC renfermant chacun le composé. Le composé possède une activité inhibitrice de la polymérase du VHC et présente par conséquent une activité anti-VHC. Le composé se révèle donc utile en tant qu'agent thérapeutique ou prophylactique pour l'hépatite C. [I] chaque symbole est tel que définit dans la description.
Abe Hiroyuki
Adachi Tsuyoshi
Doi Satoki
Iio Kiyosei
Motoda Dai
Japan Tobacco Inc.
Ridout & Maybee Llp
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