C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2684404
The present invention relates to novel monohydrochloride, dihydrochloride, monohydrobromide, maleate and methanesulphonate salts of trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and/or their hydrates and/or solvates. Moreover, the invention relates to the process for preparing the salts and their hydrates and/or solvates, to their use in the treatment and/or prevention of conditions which require modulation of dopamine receptor and to pharmaceutical compositions containing them.
L'invention concerne de nouveaux sels de monohydrochlorure, de dihydrochlorure, de monohydrobromure, de maléate et de méthanesulfonate de trans 4-{2-[4-(2,3- dichlorophényl)-pipérazine-1-yl]-éthyl}-N,N-diméthylcarbamoyl-cyclohexylamine et/ou leurs hydrates et/ou solvates. L'invention concerne de plus un procédé de préparation de ces sels et de leurs hydrates et/ou solvates, l'utilisation de ces composés pour traiter et/ou prévenir des états pathologiques nécessitant une modulation des récepteurs dopaminergiques ainsi que des compositions pharmaceutiques contenant ces composés.
Againe Csongor Eva
Czibula Laszlo
Domany Gyorgy
Greiner Istvan
Sebok Ferenc
Fetherstonhaugh & Co.
Richter Gedeon Nyrt.
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