C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/12 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 211/40 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2528644
The present invention relates to compounds of formula (I), wherein Ar, Y and G are as defined in the specification, a is 1 to 4, Z and W are carbon or nitrogen and n is 1, 2 or 3; and to pharmaceutical compositions comprising the compound of formula (I) and a pharmaceutically effective carrier; and to a method useful in treating or preventing in mammals, including humans, a disorder or condition selected from the group consisting of anxiety, depression, dysthymia, major depressive disorder, migraine, post~traumatic stress disorder, avoidant personality disorder, borderline personality disorder and phobias.
La présente invention concerne des composés de formule (I), dans laquelle Ar, Y et G sont tels que définis dans la description, a vaut de 1 à 4, Z et W sont carbone ou azote et n vaut 1, 2 ou 3. Elle concerne également des compositions pharmaceutiques renfermant le composé de formule (I) et un excipient pharmaceutiquement efficace, ainsi qu'une méthode utile pour traiter ou prévenir chez les mammifères, notamment chez l'homme, un trouble ou un état pathologique choisi dans le groupe comprenant l'anxiété, la dépression, la dysthymie, le trouble dépressif majeur, la migraine, le trouble de stress post-traumatique, le trouble de personnalité évitante, le trouble de personnalité limite et les phobies.
Lowe John Adams III
Sanner Mark Allen
Pfizer Products Inc.
Sim & Mcburney
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