C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01) C07J 43/00 (2006.01)
Patent
CA 2137684
The invention relates to novel piperazinyl-bis(alkylamino)pyrimidine derivatives of formula (I), wherein two of X, Y and Z mean a nitrogen atom each and the third one is a methine group; R1 and R2 represent, independently from each other, a pri- mary amino group bearing as substituent a branched-chain C4-8alkyl, -alkenyl or -alkynyl group, or a C4-10cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by C1-3alkyl group(s); or R1 and R2 stand together for a spiro-he- terocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as an addi- tional heteroatom; or one of R1 and R2 means an unsubstituted heterocyclic secondary amino group containing 4 to 7 car- bon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by C1-4-alkyl group(s); and n is 1 or 2, as well as their acid addition salts. The compounds of formula (I) are preferably prepared from diaminomonochloropyrimidine compounds and a corresponding piperazine component. The compounds of formula (I) have a pharmacological activity in themselves; it is more important, however, that they can be used as substituents in the preparation of lipid peroxidation-inhibiting substances.
Balogh Gabor
Czajlikne Csizer Eva
Galik Gyorgy
Lovasne Marsai Maria
Maho Sandor
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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