Novel piperidine compound and pharmaceutical thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 25/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2398388

Novel compounds having an excellent Na+ channel inhibiting activity, which are compounds of the general formula (I), salts thereof, or hydrates of both, wherein A is a ring of the general formula (IA), (II) (wherein R1 is hydrogen or the like; and R2 is hydrogen or the like), or the like; W is optionally substituted C1-6 alkylene or the like; Z is an optionally substituted C6-14 aromatic carbocyclic group or the like; and l is an integer of 0 to 6.

Cette invention se rapporte à de nouveaux composés ayant une excellente action inhibitrice des canaux Na?+¿, à des sels de ces composés, ou à des hydrates de ces composés et/ou de ces sels, ces composés étant représentés par la formule générale (I), où A représente un cycle ayant la formule générale (IA) (où R?1¿ représente hydrogène ou similaire; et R?2¿ représente hydrogène ou similaire) ou similaire; W représente alkylène C¿1?-C¿6? éventuellement substitué ou similaire; Z représente un groupe carbocyclique aromatique éventuellement substitué C¿6?-C¿14? ou similaire; et l représente un nombre entier compris entre 0 et 6.

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