C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/4523 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2562377
Novel diaminothiazoles of formula (I) are discussed. These compounds selectively inhibit the activity of Cdk4 and are thus useful in the treatment or control of cancer, in particular, the treatment or control of solid tumors. This invention also provides pharmaceutical compositions containing such compounds and methods of treating or controlling cancer, most particularly, the treatment or control of breast, lung, colon, and prostate tumors.
L'invention concerne de nouveaux diaminothiazoles de formule (I). Ces composés inhibent de manière sélective l'activité de Cdk4 et sont donc utiles pour traiter ou lutter contre le cancer, notamment pour le traitement et la lutte contre des tumeurs solides. La présente invention porte également sur des compositions pharmaceutiques contenant ces composés et sur des méthodes pour traiter ou lutter contre le cancer, notamment pour traiter ou lutter contre des tumeurs aux seins, aux poumons, au côlon et à la prostate.
Ding Qingjie
Jiang Nan
Kim Kyungjin
Lovey Allen John
Mccomas Warren William
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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