Novel pla1

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/16 (2006.01) A61K 31/711 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61P 43/00 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/20 (2006.01) C12N 15/55 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2425845

A novel phospholipase A1 (PLA1) having a substrate specificity for phosphatidic acid (PA); a peptide or a polypeptide originating in the novel PLA1; a polynucleotide encoding the peptide or the polypeptide originating in the novel PLA1; a process for producing the peptide or the polypeptide originating in the novel PLA1; an antibody against the peptide or the polypeptide originating in the novel PLA1; a method of identifying an inhibitor, an antagonist or a potentiator for the novel PLA1 by using the same; a compound identified by this method; and medicinal compositions and a diagnostic method with the use of the same.

La présente invention concerne une nouvelle phospholipase A¿1? (PLA¿1?) présentant une spécificité de substrat pour l'acide phosphatidique (PA), un peptide ou un polypeptide provenant de cette nouvelle PLA¿1?, un polynucléotide codant le peptide ou le polypeptide provenant de cette nouvelle PLA¿1?, un procédé de production du peptide ou du polypeptide provenant de cette nouvelle PLA¿1?, un anticorps luttant contre le peptide ou le polypeptide provenant de cette nouvelle PLA¿1?, un procédé d'identification d'un inhibiteur, d'un antagoniste ou d'un potentialisateur de la nouvelle PLA¿1? par utilisation de ce dernier, un composé identifié au moyen de ce procédé, ainsi que des compositions thérapeutiques et un procédé diagnostique mettant en oeuvre celles-ci.

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